Early phosphoproteomic changes in the mouse spleen during deoxynivalenol-induced ribotoxic stress.

@article{Pan2013EarlyPC,
  title={Early phosphoproteomic changes in the mouse spleen during deoxynivalenol-induced ribotoxic stress.},
  author={Xiao Cun Pan and Douglas A Whitten and Ming Wu and Christina M Chan and Curtis Gene Wilkerson and James J. Pestka},
  journal={Toxicological sciences : an official journal of the Society of Toxicology},
  year={2013},
  volume={135 1},
  pages={129-43}
}
The trichothecene mycotoxin deoxynivalenol (DON) targets the innate immune system and is of public health significance because of its frequent presence in human and animal food. DON-induced proinflammatory gene expression and apoptosis in the lymphoid tissue have been associated with a ribotoxic stress response (RSR) that involves rapid phosphorylation of mitogen-activated protein kinases (MAPKs). To better understand the relationship between protein phosphorylation and DON's immunotoxic… CONTINUE READING