Early phosphatidylinositol 3-kinase/Akt pathway activation limits poliovirus-induced JNK-mediated cell death.

@article{Autret2008EarlyP3,
  title={Early phosphatidylinositol 3-kinase/Akt pathway activation limits poliovirus-induced JNK-mediated cell death.},
  author={Arnaud Autret and Sandra Martin-Latil and Cynthia Brisac and Laurence Mousson and Florence Colb{\`e}re-Garapin and Bruno Blondel},
  journal={Journal of virology},
  year={2008},
  volume={82 7},
  pages={3796-802}
}
Poliovirus (PV)-induced apoptosis seems to play a major role in tissue injury in the central nervous system (CNS). We have previously shown that this process involves PV-induced Bax-dependent mitochondrial dysfunction mediated by early JNK activation in IMR5 neuroblastoma cells. We showed here that PV simultaneously activates the phosphatidylinositol 3-kinase (PI3K)/Akt survival signaling pathway in these cells, limiting the extent of JNK activation and thereby cell death. JNK inhibition is… CONTINUE READING

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