Early-phase insulin secretion is disturbed in obese subjects with glucose intolerance.

@article{Mizuno2007EarlyphaseIS,
  title={Early-phase insulin secretion is disturbed in obese subjects with glucose intolerance.},
  author={Akira Mizuno and Hidekazu Arai and Makiko Fukaya and Mitsuyo Sato and Yamanaka-Okumura Hisami and Eiji Takeda and Toshio Doi},
  journal={Metabolism: clinical and experimental},
  year={2007},
  volume={56 6},
  pages={856-62}
}
The loss of early-phase insulin secretion is a characteristic feature of type 2 diabetes mellitus. The aim of this study is to examine when impairment of early-phase insulin secretion occurs and whether it can be related to increase in insulin resistance caused by obesity. We developed an analytical method to qualify the early-phase insulin secretion; that is, we measured C-peptide immunoreactivity (CPR) response to a selective increase in blood glucose level in portal vein during oral glucose… CONTINUE READING
8 Citations
0 References
Similar Papers

Citations

Publications citing this paper.

Similar Papers

Loading similar papers…