Early pharmacotherapy restores neurogenesis and cognitive performance in the Ts65Dn mouse model for Down syndrome.

@article{Bianchi2010EarlyPR,
  title={Early pharmacotherapy restores neurogenesis and cognitive performance in the Ts65Dn mouse model for Down syndrome.},
  author={Patrizia Grace Bianchi and Elisabetta Ciani and Sandra Guidi and Stefania Trazzi and Daniela Felice and Gabriele Grossi and Mercedes Fern{\'a}ndez and Alessandro Giuliani and Laura Calz{\`a} and Renata Bartesaghi},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2010},
  volume={30 26},
  pages={8769-79}
}
Down syndrome (DS) is a genetic pathology characterized by intellectual disability and brain hypotrophy. Widespread neurogenesis impairment characterizes the fetal and neonatal DS brain, strongly suggesting that this defect may be a major determinant of mental retardation. Our goal was to establish, in a mouse model for DS, whether early pharmacotherapy improves neurogenesis and cognitive behavior. Neonate Ts65Dn mice were treated from postnatal day (P) 3 to P15 with fluoxetine, an… CONTINUE READING
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The mouse brain in stereotaxic coordinates

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