Early patterning of the prospective midbrain–hindbrain boundary by the HES-related gene XHR1 in Xenopus embryos

@article{Shinga2001EarlyPO,
  title={Early patterning of the prospective midbrain–hindbrain boundary by the HES-related gene XHR1 in Xenopus embryos},
  author={Jun Shinga and Mari Itoh and Koichiro Shiokawa and Sumiko Taira and Masanori Taira},
  journal={Mechanisms of Development},
  year={2001},
  volume={109},
  pages={225-239}
}
The molecular mechanisms that govern early patterning of anterior neuroectoderm (ANE) for the prospective brain region in vertebrates are largely unknown. Screening a cDNA library of Xenopus ANE led to the isolation of a Hairy and Enhancer of split- (HES)-related transcriptional repressor gene, Xenopus HES-related 1 (XHR1). XHR1 is specifically expressed in the midbrain-hindbrain boundary (MHB) region at the tailbud stage. The localized expression of XHR1 was detected as early as the early… CONTINUE READING

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