Early patterning of the mouse embryo: implications for hematopoietic commitment and differentiation.

Abstract

Prior to and during gastrulation, reciprocal interactions between embryonic and extraembryonic lineages are crucial for the correct patterning of the embryo. Several lines of investigation have underscored the importance of extraembryonic ectoderm and primitive endodermal in establishing the anterior-posterior axis of the embryo. Signals from these tissues… (More)

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