Corpus ID: 12278058

Early pathophysiological alterations in experimental cardiomyopathy: the Syrian cardiomyopathic hamster.

@article{Escobales2008EarlyPA,
  title={Early pathophysiological alterations in experimental cardiomyopathy: the Syrian cardiomyopathic hamster.},
  author={Nelson Escobales and M. Crespo},
  journal={Puerto Rico health sciences journal},
  year={2008},
  volume={27 4},
  pages={
          307-14
        }
}
  • Nelson Escobales, M. Crespo
  • Published 2008
  • Medicine
  • Puerto Rico health sciences journal
  • The Syrian cardiomyopathic hamster (SCH) is an established animal model for genetic cardiomyopathy. The disease in the hamster develops through similar stages to those observed in humans with this condition. The pathophysiological basis for this condition in the hamster resides in an inherited mutation in the gene encoding for delta-sarcoglycan, a component of the dystrophin complex. Two basic mechanisms contribute to cardiomyopathy in this model: ischemic heart disease by vasospasms of the… CONTINUE READING
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