Early paracetamol treatment associated with lowered risk of persistent ductus arteriosus in very preterm infants.

@article{Aikio2014EarlyPT,
  title={Early paracetamol treatment associated with lowered risk of persistent ductus arteriosus in very preterm infants.},
  author={Outi Aikio and Pia H{\"a}rkin and Timo Saarela and Mikko K. Hallman},
  journal={The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians},
  year={2014},
  volume={27 12},
  pages={
          1252-6
        }
}
OBJECTIVES Persistent ductus arteriosus (PDA) delays the recovery of very preterm infants (VLGA, gestation <32 weeks). Indomethacin/ibuprofen treatment and ligation of PDA have complications. As a prostaglandin synthase inhibitor paracetamol may also promote the closure of ductus arteriosus. We studied retrospectively whether early paracetamol therapy was associated with decreased incidence of PDA without adverse events. METHODS On June 2009, we introduced intravenous paracetamol during early… CONTINUE READING
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