Early or late IL-10 blockade enhances Th1 and Th17 effector responses and promotes fungal clearance in mice with cryptococcal lung infection.

@article{Murdock2014EarlyOL,
  title={Early or late IL-10 blockade enhances Th1 and Th17 effector responses and promotes fungal clearance in mice with cryptococcal lung infection.},
  author={Benjamin J. Murdock and Seagal Teitz-Tennenbaum and Gwo-hsiao Chen and Anthony J. Dils and Antoni N. Malachowski and Jeffrey L Curtis and Michal A Olszewski and John J. Osterholzer},
  journal={Journal of immunology},
  year={2014},
  volume={193 8},
  pages={4107-16}
}
The potent immunoregulatory properties of IL-10 can counteract protective immune responses and, thereby, promote persistent infections, as evidenced by studies of cryptococcal lung infection in IL-10-deficient mice. To further investigate how IL-10 impairs fungal clearance, the current study used an established murine model of C57BL/6J mice infected with Cryptococcus neoformans strain 52D. Our results demonstrate that fungal persistence is associated with an early and sustained expression of IL… CONTINUE READING
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