Early onset senescence occurs when fibroblasts lack the glutamate-cysteine ligase modifier subunit.

@article{Chen2009EarlyOS,
  title={Early onset senescence occurs when fibroblasts lack the glutamate-cysteine ligase modifier subunit.},
  author={Yin Chen and Elisabet Johansson and Yunxia Fan and Howard G. Shertzer and Vasilis Vasiliou and Daniel W. Nebert and Timothy P. Dalton},
  journal={Free radical biology & medicine},
  year={2009},
  volume={47 4},
  pages={410-8}
}
Cellular senescence is the irreversible entry of cells into growth arrest. Senescence of primary cells in culture has long been used as an in vitro model for aging. Glutamate-cysteine ligase (GCL) controls the synthetic rate of the important cellular antioxidant glutathione (GSH). The catalytic subunit of GCL, GCLC, is catalytically active and essential for life. By contrast the modifier subunit of GCL, GCLM, is dispensable in mice. Although it is recognized that GCLM increases the rate of GSH… CONTINUE READING

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