Early onset of primary hypogonadism revealed by serum anti-Müllerian hormone determination during infancy and childhood in trisomy 21.

@article{Grinspon2011EarlyOO,
  title={Early onset of primary hypogonadism revealed by serum anti-M{\"u}llerian hormone determination during infancy and childhood in trisomy 21.},
  author={Romina Paula Grinspon and Patricia Bedecarr{\'a}s and Mar{\'i}a Gabriela Ballerini and Germ{\'a}n {\'I}{\~n}iguez and Ademir Rocha and E A Mantovani Rodrigues Resende and Vin{\'i}cius Nahime de Brito and Carlos R. S. Milani and V Figueroa Gacit{\'u}a and Alberto Chiesa and Ana Claudia Keselman and Silvia Gottlieb and M F{\'a}tima Borges and Mar{\'i}a Gabriela Ropelato and J-Y Picard and Ethel Codner and Rodolfo Alberto Rey},
  journal={International journal of andrology},
  year={2011},
  volume={34 5 Pt 2},
  pages={e487-98}
}
Male patients with an extra sex chromosome or autosome are expected to present primary hypogonadism at puberty owing to meiotic germ-cell failure. Scarce information is available on trisomy 21, a frequent autosomal aneuploidy. Our objective was to assess whether trisomy 21 presents with pubertal-onset, germ-cell specific, primary hypogonadism in males, or whether the hypogonadism is established earlier and affects other testicular cell populations. We assessed the functional status of the… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 20 extracted citations

Similar Papers

Loading similar papers…