Early onset of Runx2 expression caused craniosynostosis, ectopic bone formation, and limb defects.

@article{Maeno2011EarlyOO,
  title={Early onset of Runx2 expression caused craniosynostosis, ectopic bone formation, and limb defects.},
  author={Takafumi Maeno and Takeshi Moriishi and Carolina Andrea Yoshida and Hisato Komori and Naoko Kanatani and S Izumi and Kunio Takaoka and Toshihisa Komori},
  journal={Bone},
  year={2011},
  volume={49 4},
  pages={673-82}
}
RUNX2 is an essential transcription factor for osteoblast differentiation, because osteoblast differentiation is completely blocked in Runx2-deficient mice. However, it remains to be clarified whether RUNX2 is sufficient for osteoblast differentiation during embryogenesis. To address this issue, Runx2 transgenic mice were generated under the control of the Prrx1 promoter, which directs the transgene expression to mesenchymal cells before the onset of bone development. The transgene expression… CONTINUE READING

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