Early-onset metabolic syndrome in mice lacking the intestinal uric acid transporter SLC2A9.

@article{DeBosch2014EarlyonsetMS,
  title={Early-onset metabolic syndrome in mice lacking the intestinal uric acid transporter SLC2A9.},
  author={Brian J DeBosch and Oliver Kluth and Hideji Fujiwara and Annette Sch{\"u}rmann and Kelle H Moley},
  journal={Nature communications},
  year={2014},
  volume={5},
  pages={4642}
}
Excess circulating uric acid, a product of hepatic glycolysis and purine metabolism, often accompanies metabolic syndrome. However, whether hyperuricaemia contributes to the development of metabolic syndrome or is merely a by-product of other processes that cause this disorder has not been resolved. In addition, how uric acid is cleared from the circulation is incompletely understood. Here we present a genetic model of spontaneous, early-onset metabolic syndrome in mice lacking the enterocyte… CONTINUE READING

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