Early-onset macular degeneration with drusen in a cynomolgus monkey (Macaca fascicularis) pedigree: exclusion of 13 candidate genes and loci.

@article{Umeda2005EarlyonsetMD,
  title={Early-onset macular degeneration with drusen in a cynomolgus monkey (Macaca fascicularis) pedigree: exclusion of 13 candidate genes and loci.},
  author={Shinsuke Umeda and Radha Ayyagari and Rando L. Allikmets and Michihiro T. Suzuki and Athancios J Karoukis and Rajesh Ambasudhan and Jana Zernant and Haru Okamoto and Fumiko Ono and Keiji Terao and Atsushi Mizota and Yasuhiro Yoshikawa and Yasuhiko Tanaka and Takeshi Iwata},
  journal={Investigative ophthalmology & visual science},
  year={2005},
  volume={46 2},
  pages={683-91}
}
PURPOSE To describe hereditary macular degeneration observed in the cynomolgus monkey (Macaca fascicularis), which shares phenotypic features with age-related macular degeneration in humans, and to test the involvement of candidate gene loci by mutation screening and linkage analysis. METHODS Ophthalmic examinations with fundus photography, fluorescein angiography (FA), indocyanine green angiography (IA), electroretinography (ERG), and histologic studies were performed on both affected and… CONTINUE READING

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