Early-onset lymphoproliferation and autoimmunity caused by germline STAT3 gain-of-function mutations.

Abstract

Germline loss-of-function mutations in the transcription factor signal transducer and activator of transcription 3 (STAT3) cause immunodeficiency, whereas somatic gain-of-function mutations in STAT3 are associated with large granular lymphocytic leukemic, myelodysplastic syndrome, and aplastic anemia. Recently, germline mutations in STAT3 have also been… (More)
DOI: 10.1182/blood-2014-09-602763

Topics

2 Figures and Tables