Early-onset liver cancer in South America associates with low hepatitis B virus DNA burden

  title={Early-onset liver cancer in South America associates with low hepatitis B virus DNA burden},
  author={A. Marchio and J. Cerapio and E. Ruiz and Luis Cano and S. Casavilca and B. Terris and E. Deharo and A. Dejean and S. Bertani and P. Pineau},
  journal={Scientific Reports},
In Peru, hepatocellular carcinoma (HCC) arises in young non-cirrhotic patients. Hepatitis B virus (HBV) is suspected to be the prominent etiological agent. We thus performed a comprehensive molecular study of HBV infection in 65 Peruvian HCC patients. Only 51% were considered as persistently infected at the onset. HBV DNA was found by PCR in the tumor and/or matched non-tumor liver tissues in more than 80% of cases (n = 53/65). HBV DNA was significantly more abundant in livers of younger… Expand
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  • 2008
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