Early onset deficits on the delayed alternation task in the Hdh(Q92) knock-in mouse model of Huntington's disease.

@article{Trueman2012EarlyOD,
  title={Early onset deficits on the delayed alternation task in the Hdh(Q92) knock-in mouse model of Huntington's disease.},
  author={Rebecca C. Trueman and Lesley Jones and Stephen B. Dunnett and S. P. Brooks},
  journal={Brain research bulletin},
  year={2012},
  volume={88 2-3},
  pages={156-62}
}
A number of genetic mouse models of Huntington's disease have been created, in order to examine the pathogenesis of Huntington's disease and to test potential therapeutics. In the present study we demonstrate that the full-length knock-in homozygote Hdh(Q92) mice exhibit impairments at 5 months of age on the delayed alternation task, conducted in 9-hole… CONTINUE READING