Early occurrence of RASSF1A hypermethylation and its mutual exclusion with BRAF mutation in thyroid tumorigenesis.

@article{Xing2004EarlyOO,
  title={Early occurrence of RASSF1A hypermethylation and its mutual exclusion with BRAF mutation in thyroid tumorigenesis.},
  author={Mingzhao Xing and Yoram Cohen and Elizabeth Mambo and G. Tallini and Robert D Udelsman and Paul Ladenson and David Sidransky},
  journal={Cancer research},
  year={2004},
  volume={64 5},
  pages={1664-8}
}
Follicular epithelial cell-derived thyroid tumors are common neoplasms comprised mainly of benign thyroid adenomas, follicular thyroid cancers, and papillary thyroid cancers (PTCs). Hypermethylation of the tumor suppressor gene RASSF1A and activating mutation of BRAF gene have been reported recently in thyroid cancers. To additionally investigate the roles of these two epigenetic/genetic alterations in thyroid tumor progression, we examined their occurrences and relationship in both benign and… CONTINUE READING
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