Early obstruction of decellularized xenogenic valves in pediatric patients: involvement of inflammatory and fibroproliferative processes.

@article{Cicha2011EarlyOO,
  title={Early obstruction of decellularized xenogenic valves in pediatric patients: involvement of inflammatory and fibroproliferative processes.},
  author={Iwona Cicha and Andr{\'e} Rueffer and Robert Anton Cesnjevar and Martin Gl{\"o}ckler and Abbas Agaimy and Werner Guenther Daniel and Christoph D. Garlichs and Sven Dittrich},
  journal={Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology},
  year={2011},
  volume={20 4},
  pages={222-31}
}
BACKGROUND Decellularization of pulmonary valve substitutes is believed to eliminate immunogenicity and improve conduit durability. This study focused on a detailed histopathological and immunohistochemical analysis of explanted Matrix P plus valves, following their early obstruction in pediatric patients. METHODS Occurrence of fibrosis, scar formation, neovascularization, and inflammatory infiltrates were determined in longitudinal sections of four valve specimens explanted after 12-15… CONTINUE READING
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