Early nuclear events in lymphocyte proliferation. The role of DNA strand break repair and ADP ribosylation.

@article{Greer1986EarlyNE,
  title={Early nuclear events in lymphocyte proliferation. The role of DNA strand break repair and ADP ribosylation.},
  author={Wenda L. Greer and J. Gordin Kaplan},
  journal={Experimental cell research},
  year={1986},
  volume={166 2},
  pages={399-415}
}
The previously reported extensive DNA strand breakage in resting murine splenic lymphocytes is not an artifact of the extraction or assay procedure. The benzamide inhibitors of poly(ADP ribose) synthetase (pADPRS), such as 5-methoxybenzamide (MBA), had been shown to block the strand break repair occurring within 2 h of activation of splenic lymphocytes by the mitogen concanavalin A (conA); the inhibitors also blocked early events in proliferation, such as blast formation, as well as entry into… CONTINUE READING