Early nongenomic events in aldosterone action in renal collecting duct cells: PKCalpha activation, mineralocorticoid receptor phosphorylation, and cross-talk with the genomic response.

@article{Mollic2004EarlyNE,
  title={Early nongenomic events in aldosterone action in renal collecting duct cells: PKCalpha activation, mineralocorticoid receptor phosphorylation, and cross-talk with the genomic response.},
  author={Cathy Le Mo{\"e}llic and Antoine Ouvrard-Pascaud and Claudia Capurro and Françoise Cluzeaud and Michel Fay and Fr{\'e}d{\'e}ric Jaisser and Nicolette Farman and Marcel Blot-Chabaud},
  journal={Journal of the American Society of Nephrology : JASN},
  year={2004},
  volume={15 5},
  pages={1145-60}
}
Effects of aldosterone on its target cells have long been considered to be mediated exclusively through the genomic pathway; however, evidence has been provided for rapid effects of the hormone that may involve nongenomic mechanisms. Whether an interaction exists between these two signaling pathways is not yet established. In this study, the authors show that aldosterone triggers both early nongenomic and late genomic increase in sodium transport in the RCCD(2) rat cortical collecting duct cell… CONTINUE READING

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