Early neutralizing IgG response to Chikungunya virus in infected patients targets a dominant linear epitope on the E2 glycoprotein

@inproceedings{Kam2012EarlyNI,
  title={Early neutralizing IgG response to Chikungunya virus in infected patients targets a dominant linear epitope on the E2 glycoprotein},
  author={Y. L. K. Kam and Fok-Moon Lum and Teck-Hui Teo and Wendy W. L. Lee and Diane Simarmata and Sumitro Harjanto and Chong-Long Chua and Yoke-Fun Chan and Jin-Kiat Wee and Angela Chow and Raymond Tze Pin Lin and Yee Sin Leo and Roger Le Grand and I-Ching Sam and Joo-Chuan Tong and Pierre Roques and K H Wiesm{\"u}ller and Laurent R{\'e}nia and Olaf Roetzschke and Lisa F P Ng},
  booktitle={EMBO molecular medicine},
  year={2012}
}
Chikungunya virus (CHIKV) and related arboviruses have been responsible for large epidemic outbreaks with serious economic and social impact. The immune mechanisms, which control viral multiplication and dissemination, are not yet known. Here, we studied the antibody response against the CHIKV surface antigens in infected patients. With plasma samples obtained during the early convalescent phase, we showed that the naturally-acquired IgG response is dominated by IgG3 antibodies specific mostly… CONTINUE READING

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