Early neuropathological Alzheimer's changes in aged individuals are accompanied by decreased cerebrospinal fluid melatonin levels.

@article{Zhou2003EarlyNA,
  title={Early neuropathological Alzheimer's changes in aged individuals are accompanied by decreased cerebrospinal fluid melatonin levels.},
  author={Jiang-Ning Zhou and Rong-yu Liu and Wouter Kamphorst and Michel A. Hofman and Dick F. Swaab},
  journal={Journal of pineal research},
  year={2003},
  volume={35 2},
  pages={125-30}
}
Neuropathology is the most reliable criterion for diagnosing Alzheimer's disease (AD). A well-established system for staging the spread of neuropathological changes in AD is available. The clinical use of a biomarker that reflects the neuropathological change occurring in brain tissue has not yet been established. Melatonin is a product that plays not only a major role in the regulation of the circadian rhythms but may also exert neuroprotective effects in AD. Melatonin levels were determined… CONTINUE READING
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