Early neuropathologic effects of mild or moderate hypoxemia after controlled cortical impact injury in rats.

@article{Clark1997EarlyNE,
  title={Early neuropathologic effects of mild or moderate hypoxemia after controlled cortical impact injury in rats.},
  author={Robert B. Clark and Patrick M Kochanek and Clifton Edward Dixon and Ming Chen and Donald W. Marion and S M Heineman and Steven DeKosky and Steven H Graham},
  journal={Journal of neurotrauma},
  year={1997},
  volume={14 4},
  pages={179-89}
}
Hypoxemia has detrimental effects after traumatic brain injury (TBI) in both experimental models and humans. The purpose of this study was to determine the effect of mild or moderate hypoxemia on early histologic and motor functional outcome after controlled cortical impact (CCI) in rats. Anesthetized rats underwent CCI and were randomized to receive mild (FiO2 = 13%, n = 6), moderate (FiO2 = 11%, n = 9), or no (FiO2 = 33%, n = 6) hypoxemia for 30 min after trauma. Sham-operated rats without… CONTINUE READING
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