Early neuronal dysfunction by amyloid β oligomers depends on activation of NR2B-containing NMDA receptors.

  title={Early neuronal dysfunction by amyloid β oligomers depends on activation of NR2B-containing NMDA receptors.},
  author={Raik R{\"o}nicke and Marina Mikhaylova and Sabine R{\"o}nicke and Jessica Meinhardt and Ulrich H. Schr{\"o}der and Marcus F{\"a}ndrich and Georg Reiser and Michael R Kreutz and Klaus G. Reymann},
  journal={Neurobiology of aging},
  volume={32 12},
Several studies indicate that NMDA receptor signaling is involved in Aβ oligomer-mediated impairment of neuronal function and morphology. Utilizing primary neuronal cell culture and hippocampal slices from rat and mouse, we found that Aβ oligomer administration readily impairs long-term potentiation, reduces baseline synaptic transmission, decreases neuronal spontaneous network activity and induces retraction of synaptic contacts long before major cytotoxic effects are visible. Interestingly… CONTINUE READING
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