Early neurodegeneration in the retina of type 2 diabetic patients.

@article{Dijk2012EarlyNI,
  title={Early neurodegeneration in the retina of type 2 diabetic patients.},
  author={H. V. van Dijk and F. Verbraak and P. Kok and M. Stehouwer and M. Garvin and M. Sonka and J. DeVries and R. Schlingemann and M. Abr{\`a}moff},
  journal={Investigative ophthalmology \& visual science},
  year={2012},
  volume={53 6},
  pages={
          2715-9
        }
}
PURPOSE The purpose of this study was to determine whether diabetes type 2 causes thinning of retinal layers as a sign of neurodegeneration and to investigate the possible relationship between this thinning and duration of diabetes mellitus, diabetic retinopathy (DR) status, age, sex, and glycemic control (HbA1c). METHODS Mean layer thickness was calculated for retinal layers following automated segmentation of spectral domain optical coherence tomography images of diabetic patients with no… Expand
Neurodegeneration in Type 2 Diabetes: Evidence From Spectral-Domain Optical Coherence Tomography.
TLDR
Early thinning on the inner retina happens in type 2 diabetes, even before visible vascular signs of DR, which supports the presence of a neurodegenerative process in eyes of patients with diabetes and warrants neuroprotective intervention to prevent chronic neurodegenersation. Expand
Progression of retinal neurodegeneration in patients with diabetes mellitus irrespective of presence or progression of retinal vasculopathy
Purpose: This longitudinal study investigated the change of inner retinal layer thickness in patients with diabetes mellitus type 1 and no or minimal diabetic retinopathy, and its association withExpand
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TLDR
Early structural damage of neuroretina in persons with Type 1 DM patients is related to glucose fluctuations, and GV should be addressed, even in the presence of a good metabolic control. Expand
Retinal Neurovascular Changes Appear Earlier in Type 2 Diabetic Patients
TLDR
Type 2 diabetic patients without retinopathy and with early-stage Retinopathy have inferior thickness values of GCC and choroid compared to controls, and Insulin resistance might be a possible adjunctive pathogenetic aspect of neurodegeneration. Expand
Retinal Neurodegeneration in Diabetic Patients Without Diabetic Retinopathy.
TLDR
Overall, groups I and III of diabetic patients had a decrease in the photoreceptor layer (PR) thickness, when compared with the nondiabetic subjects in six ETDRS areas, suggesting that some form of neurodegeneration may take place before clinical signs of vascular problems arise. Expand
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TLDR
Early alterations of chorioretinal structure and retinal superficial vessels in T2DM patients even before the onset of clinical signs of DR are reported and found to be positively related with VD in diabetic patients without DR. Expand
The spatial relation of diabetic retinal neurodegeneration with diabetic retinopathy
TLDR
RNFL and GCL both showed thinning over time, which was more pronounced in eyes with DR for GCL, and quadrant analyses showed similar results, showing that structural DRN is associated with DR per quadrant independently. Expand
Alterations in retinal nerve fiber layer thickness in early stages of diabetic retinopathy and potential risk factors
TLDR
RNFL loss might be the earliest structural change of retina in diabetic patients, and associated with diabetic duration, BMI, TG, HbA1c, and ACR, according to Pearson correlation analysis. Expand
Multimodal Imaging Assessment of Vascular and Neurodegenerative Retinal Alterations in Type 1 Diabetic Patients without Fundoscopic Signs of Diabetic Retinopathy
TLDR
Results suggest that vascular alterations could be the first detectable retinal change in the development of type 1 diabetes mellitus without diabetic retinopathy. Expand
Structural neurodegeneration correlates with early diabetic retinopathy
TLDR
In patients with type 2 diabetes, structural neurogenic characteristics were associated with DR, which may indicate that a complex neurovascular interaction is an early event in the pathogenesis of DR. Expand
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References

SHOWING 1-10 OF 34 REFERENCES
Decreased retinal ganglion cell layer thickness in type 1 diabetic patients
Purpose: To determine which retinal layers are most affected by diabetes and contribute to thinning of the inner retina, and to investigate the relationship between retinal layer thickness (LT) andExpand
Decreased retinal ganglion cell layer thickness in patients with type 1 diabetes.
TLDR
The concept that diabetes has an early neurodegenerative effect on the retina, which occurs even though the vascular component of DR is minimal, is supported. Expand
Selective loss of inner retinal layer thickness in type 1 diabetic patients with minimal diabetic retinopathy.
TLDR
Thinning of the total retina in type 1 diabetic patients with minimal retinopathy compared with healthy controls is attributed to a selective thinning of inner retinal layers and supports the concept that early DR includes a neurodegenerative component. Expand
Association of visual function and ganglion cell layer thickness in patients with diabetes mellitus type 1 and no or minimal diabetic retinopathy
TLDR
This study evaluated the possible relationship between structure and function in patients with type 1 diabetes mellitus and no or minimal diabetic retinopathy and demonstrated loss of macular visual function and corresponding thinning of the ganglion cell layer (GCL) in the pericentral area of the macula of diabetic patients. Expand
ADOLESCENTS WITH TYPE 2 DIABETES: Early Indications of Focal Retinal Neuropathy, Retinal Thinning, and Venular Dilation
TLDR
Early indications of focal retinal neuropathy, retinal thinning, and venular dilation in adolescents with Type 2 diabetes are shown. Expand
Early detection of retinal thickness changes in diabetes using Optical Coherence Tomography.
  • D. Cabrera DeBuc, G. Somfai
  • Medicine
  • Medical science monitor : international medical journal of experimental and clinical research
  • 2010
TLDR
The results support the view of neurodegeneration in diabetes in the early stage of retinopathy which seems to involve the ganglion cells and cells of the inner plexiform layers (RNFL+GCL+IPL) mostly. Expand
A new view of diabetic retinopathy: a neurodegenerative disease of the eye
  • A. Barber
  • Biology, Medicine
  • Progress in Neuro-Psychopharmacology and Biological Psychiatry
  • 2003
TLDR
Evidence presented here suggests that apoptosis of neurons is also an essential target for pharmacological studies, which suggests that the vision of people with diabetes will be protected only when the authors have discovered a means to prevent the gradual but constant loss of neurons within the inner retina. Expand
Decreased optical coherence tomography-measured pericentral retinal thickness in patients with diabetes mellitus type 1 with minimal diabetic retinopathy
TLDR
A significantly decreased pericentral RT was measured in patients with minimal DR compared to healthy controls, which could be explained by a loss of intraretinal neural tissue in the earliest stage of DR. Expand
Early detection of macular changes in patients with diabetes using Rarebit Fovea Test and optical coherence tomography
TLDR
Low retinal thickness and subnormal RFT results were found in a subgroup of diabetes patients, despite normal screening results, and Prospective studies are under way to evaluate the prognostic implications. Expand
Changes of macular and RNFL thicknesses measured by Stratus OCT in patients with early stage diabetes
TLDR
At the early stage of diabetic retinopathy, the maculas and RNFL thicknesses are altered and are different in men and women. Expand
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