Early neonatal death in mice homozygous for a null allele of the insulin receptor gene

  title={Early neonatal death in mice homozygous for a null allele of the insulin receptor gene},
  author={Domenico Accili and John L Drago and Eric Lee and Mark D. Johnson and Martha H. Cool and Paola Salvatore and Laureano D. Asico and Pedro A. Jos{\'e} and Simeon I Taylor and Heiner Westphal},
  journal={Nature Genetics},
Insulin action is viewed as a set of branching pathways, with some actions serving to regulate energy metabolism and others to regulate cellular growth and development1. Thus far, available genetic evidence has supported this view. In humans, complete lack of insulin receptors due to mutations of the insulin receptor gene results in severe growth retardation and mild diabetes2,3. In mice, targeted inactivation of insulin receptor sub-strate-1, an important substrate of the insulin receptor… CONTINUE READING


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