Early myotome specification regulates PDGFA expression and axial skeleton development.

  title={Early myotome specification regulates PDGFA expression and axial skeleton development.},
  author={Michelle D. Tallquist and Kaare Weismann and Mats Hellstr{\"o}m and Philippe Soriano},
  volume={127 23},
Reciprocal defects in signaling between the myotome and the sclerotome compartments of the somites in PDGFRalpha and Myf5 mutant embryos lead to alterations in the formation of the vertebrae and the ribs. To investigate the significance of these observations, we have examined the role of PDGF signaling in the developing somite. PDGFA ligand expression was not detected in the myotome of Myf5 null mutant embryos and PDGFA promoter activity was regulated by Myf5 in vitro. PDGFA stimulated… CONTINUE READING
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