Early mouse endoderm is patterned by soluble factors from adjacent germ layers.

@article{Wells2000EarlyME,
  title={Early mouse endoderm is patterned by soluble factors from adjacent germ layers.},
  author={James M Wells and Douglas A. Melton},
  journal={Development},
  year={2000},
  volume={127 8},
  pages={1563-72}
}
Endoderm that forms the respiratory and digestive tracts is a sheet of approximately 500-1000 cells around the distal cup of an E7.5 mouse embryo. Within 2 days, endoderm folds into a primitive gut tube from which numerous organs will bud. To characterize the signals involved in the developmental specification of this early endoderm, we have employed an in vitro assay using germ layer explants and show that adjacent germ layers provide soluble, temporally specific signals that induce organ… CONTINUE READING

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