Early motor disturbances in Rett syndrome and its pathophysiological importance

  title={Early motor disturbances in Rett syndrome and its pathophysiological importance},
  author={M. Segawa},
  journal={Brain and Development},
  • M. Segawa
  • Published 2005
  • Psychology, Medicine
  • Brain and Development
  • Assessment of the development of motor function of Rett syndrome (RTT) revealed hypotonia with failure of crawling and disturbance in skillful hand manipulation are shown as early motor signs. Clinical evaluation has revealed the former as postural hypotonia with failure in locomotion and neurophysiological examinations have showed this to be due to hypofunction of the aminergic neurons of the brainstem. The latter signs are considered to indicate dysfunction of the corticospinal tract at… CONTINUE READING
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