Early motor disturbances in Rett syndrome and its pathophysiological importance
@article{Segawa2005EarlyMD, title={Early motor disturbances in Rett syndrome and its pathophysiological importance}, author={M. Segawa}, journal={Brain and Development}, year={2005}, volume={27}, pages={s54-s58} }
Assessment of the development of motor function of Rett syndrome (RTT) revealed hypotonia with failure of crawling and disturbance in skillful hand manipulation are shown as early motor signs. Clinical evaluation has revealed the former as postural hypotonia with failure in locomotion and neurophysiological examinations have showed this to be due to hypofunction of the aminergic neurons of the brainstem. The latter signs are considered to indicate dysfunction of the corticospinal tract at… CONTINUE READING
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References
SHOWING 1-10 OF 36 REFERENCES
Pathophysiology of Rett syndrome from the stand point of clinical characteristics
- Medicine
- Brain and Development
- 2001
- 24
Rett syndrome—Clinical studies and pathophysiological consideration
- Medicine
- Brain and Development
- 1984
- 126
Motor symptoms of the Rett syndrome: abnormal muscle tone, posture, locomotion and stereotyped movement.
- Medicine
- Brain & development
- 1992
- 37
[Neuropathology and immunohistochemistry of brains with Rett syndrome].
- Medicine
- No to hattatsu = Brain and development
- 2002
- 15
Excitotoxic lesions of the pedunculopontine tegmental nucleus produce contralateral hemiparkinsonism in the monkey
- Medicine
- Neuroscience Letters
- 1997
- 157