Early molecular events in the assembly of the focal adhesion-stress fiber complex during fibroblast spreading.

@article{Zimerman2004EarlyME,
  title={Early molecular events in the assembly of the focal adhesion-stress fiber complex during fibroblast spreading.},
  author={Baruch Zimerman and Tova Volberg and Benjamin Geiger},
  journal={Cell motility and the cytoskeleton},
  year={2004},
  volume={58 3},
  pages={143-59}
}
Cell adhesion to the extracellular matrix triggers the formation of integrin-mediated contact and reorganization of the actin cytoskeleton. Examination of nascent adhesions, formed during early stages of fibroblast spreading, reveals a variety of forms of actin-associated matrix adhesions. These include: (1). small ( approximately 1 microm), dot-like, integrin-, vinculin-, paxillin-, and phosphotyrosine-rich structures, with an F-actin core, broadly distributed over the ventral surfaces of the… CONTINUE READING

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