Early molecular events in the assembly of matrix adhesions at the leading edge of migrating cells.

@article{ZaidelBar2003EarlyME,
  title={Early molecular events in the assembly of matrix adhesions at the leading edge of migrating cells.},
  author={Ronen Zaidel-Bar and Christoph Ballestrem and Zvi Kam and Benjamin Geiger},
  journal={Journal of cell science},
  year={2003},
  volume={116 Pt 22},
  pages={4605-13}
}
Cellular locomotion is driven by repeated cycles of protrusion of the leading edge, formation of new matrix adhesions and retraction of the trailing edge. In this study we addressed the molecular composition and dynamics of focal complexes, formed under the leading lamellae of motile cells, and their maturation into focal adhesions. We combined phase-contrast and fluorescence microscopy approaches to monitor the incorporation of phosphotyrosine and nine different focal adhesion proteins into… CONTINUE READING
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adhesion

  • D. Ilic, Y. Furuta, +7 authors T. Yamamoto
  • 1995
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migration : a physically integrated molecular process

  • C. M. Laukaitis, D. J. Webb, K. Donais, A. F. Horwitz
  • Cell
  • 2001
Highly Influential
4 Excerpts

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