Early microbiological response to linezolid vs vancomycin in ventilator-associated pneumonia due to methicillin-resistant Staphylococcus aureus.

@article{Wunderink2008EarlyMR,
  title={Early microbiological response to linezolid vs vancomycin in ventilator-associated pneumonia due to methicillin-resistant Staphylococcus aureus.},
  author={Richard G Wunderink and Meryl H Mendelson and Michael S Somero and Timothy C. Fabian and Addison K. May and Helen Bhattacharyya and Kenneth V. Leeper and Joseph S. Solomkin},
  journal={Chest},
  year={2008},
  volume={134 6},
  pages={
          1200-1207
        }
}
BACKGROUND Methicillin-resistant Staphylococcus aureus (MRSA) is a common cause of ventilator-associated pneumonia (VAP). This prospective, open-label, multicenter clinical trial compared the early microbiological efficacy of linezolid (LZD) therapy with that of vancomycin (VAN) therapy in patients with MRSA VAP. METHODS A total of 149 patients with suspected MRSA VAP were randomized to receive either LZD, 600 mg, or VAN, 1 g every 12 h. Patients with baseline bronchoscopic BAL (BBAL) fluid… CONTINUE READING

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