Early metabolic responses to lithium/pilocarpine-induced status epilepticus in rat brain.

Abstract

The lithium-pilocarpine model of status epilepticus is a well-known animal model of temporal lobe epilepsy. We combined this model with in vivo microdialysis to investigate energy metabolites and acute cellular membrane damage during seizure development. Rats were implanted with dialysis probes and pretreated with lithium chloride (127 mg/kg i.p.). Twenty… (More)
DOI: 10.1111/jnc.13360

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