Early maternal separation followed by later stressors leads to dysregulation of the HPA-axis and increases in hippocampal NGF and NT-3 levels in a rat model

@article{Faure2006EarlyMS,
  title={Early maternal separation followed by later stressors leads to dysregulation of the HPA-axis and increases in hippocampal NGF and NT-3 levels in a rat model},
  author={Jacqueline Faure and Joachim De Klerk Uys and Lelanie Marais and Dan J. Stein and Willie Mark Uren Daniels},
  journal={Metabolic Brain Disease},
  year={2006},
  volume={21},
  pages={172-179}
}
Early adverse life events, followed by subsequent stressors, appear to increase susceptibility for subsequent onset of psychiatric disorders in humans. The molecular mechanisms that underlie this phenomenon remain unclear, but dysregulation of the HPA axis and alterations in neurotrophic factors have been implicated. The present study investigated the effects in rodents of early maternal separation, followed by stress in adolescence and adulthood on later HPA-axis activity and hippocampal… CONTINUE READING
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