Early maternal deprivation reduces prepulse inhibition and impairs spatial learning ability in adulthood: no further effect of post-pubertal chronic corticosterone treatment.

@article{Garner2007EarlyMD,
  title={Early maternal deprivation reduces prepulse inhibition and impairs spatial learning ability in adulthood: no further effect of post-pubertal chronic corticosterone treatment.},
  author={Belinda Garner and Stephen J Wood and Christos Pantelis and Maarten van den Buuse},
  journal={Behavioural brain research},
  year={2007},
  volume={176 2},
  pages={323-32}
}
Prolonged maternal deprivation leads to long-term alterations in hypothalamic-pituitary-adrenal (HPA) axis activity, disturbances of auditory information processing and neurochemical changes in the adult brain, some of which are similar to that observed in schizophrenia. Here we report the adult behavioural effects of maternal deprivation (12h on postnatal days 9 and 11) in Wistar rats on paradigms of auditory information processing (prepulse inhibition), sensitivity to dopamimetics… CONTINUE READING