Early maternal deprivation induces gender-dependent changes on the expression of hippocampal CB(1) and CB(2) cannabinoid receptors of neonatal rats.

@article{Surez2009EarlyMD,
  title={Early maternal deprivation induces gender-dependent changes on the expression of hippocampal CB(1) and CB(2) cannabinoid receptors of neonatal rats.},
  author={Juan Su{\'a}rez and Ricardo Llorente and Silvana Y Romero-Zerbo and Beatriz Mateos and Francisco-Javier Berm{\'u}dez-Silva and Fernando Rodr{\'i}guez de Fonseca and M. A. Viveros},
  journal={Hippocampus},
  year={2009},
  volume={19 7},
  pages={623-32}
}
Early maternal deprivation (MD) in rats (24 h, postnatal day 9-10) is a model for neurodevelopmental stress. There are some data proving that MD affects the endocannabinoid system (ECS) in a gender-dependent manner, and that these changes may account for the proposed schizophrenia-like phenotype of MD rats. The impact of MD on cannabinoid receptor distribution in the hippocampus is unknown. The aim of this study is to evaluate the expression of CB(1) and CB(2) receptors in diverse relevant… CONTINUE READING

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