Early manifestations of vitamin D effects in rat osteogenic sarcoma cells

We have recently demonstrated that 48 hour exposure of ROS 17/2 cells to low concentrations of 1,25-dihydroxycholecalciferol (1,25-(OH)2D3) (1.0 pg/ml) stimulated the cellular accumulation of45Ca, and exposure to high concentrations (160 pg/ml) inhibited such accumulation. In the present study, short-term (15 min) effects of the sterol on45Ca accumulation… CONTINUE READING