Early manifestations and mechanism of the neurotoxic action of organophosphorus pesticides

@article{Kagan2004EarlyMA,
  title={Early manifestations and mechanism of the neurotoxic action of organophosphorus pesticides},
  author={Y. Kagan and N. Kokshareva and I. Tkachenko},
  journal={Bulletin of Experimental Biology and Medicine},
  year={2004},
  volume={102},
  pages={1227-1230}
}
The inhibition of neurotoxic esterase activity in chicken brain has been studied in vitro and in vivo. Aphos exposure, causing chicken paralysis, has demonstrated that the initial stage of delayed neurotoxicity was significant esterase activity inhibition (by 60-80%) within 3-24 hours after the pesticide administration. The inhibition of cholinesterase activity occurred both in the blood and sciatic nerve. The delayed conduction through peripheral nerves caused by demyelination has been… Expand
2 Citations
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