Early life stress paradigms in rodents: potential animal models of depression?

  title={Early life stress paradigms in rodents: potential animal models of depression?},
  author={Mathias V Schmidt and Xiao-Dong Wang and Onno C. Meijer},
While human depressive illness is indeed uniquely human, many of its symptoms may be modeled in rodents. Based on human etiology, the assumption has been made that depression-like behavior in rats and mice can be modulated by some of the powerful early life programming effects that are known to occur after manipulations in the first weeks of life. Here we review the evidence that is available in literature for early life manipulation as risk factors for the development of depression-like… CONTINUE READING
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