Early life stress combined with serotonin 3A receptor and brain-derived neurotrophic factor valine 66 to methionine genotypes impacts emotional brain and arousal correlates of risk for depression.

@article{Gatt2010EarlyLS,
  title={Early life stress combined with serotonin 3A receptor and brain-derived neurotrophic factor valine 66 to methionine genotypes impacts emotional brain and arousal correlates of risk for depression.},
  author={Justine M. Gatt and Charles B. Nemeroff and Peter R. Schofield and Robert H. Paul and C. Richard Clark and Evian Gordon and Leanne M. Williams},
  journal={Biological psychiatry},
  year={2010},
  volume={68 9},
  pages={818-24}
}
BACKGROUND Depression will be the second largest burden of disease by 2020. Developing new tools for identifying risk and ultimately prevention of depression relies on elucidating the integrative relationships between susceptibility markers from gene-stress interactions and how they impact emotional brain and arousal systems. They have largely been studied in isolation. METHODS We examined how genetic (brain-derived neurotrophic factor [BDNF] valine 66 to methionine [Val66Met] and serotonin… CONTINUE READING

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