Early-life stress, corticotropin-releasing factor, and serotonin transporter gene: a pilot study.

@article{Coplan2011EarlylifeSC,
  title={Early-life stress, corticotropin-releasing factor, and serotonin transporter gene: a pilot study.},
  author={Jeremy D. Coplan and Chadi G. Abdallah and J. G. Kaufman and Joel Gelernter and Eric L. P. Smith and T. J. D. R. Perera and Andrew J. Dwork and Arie Kaffman and J. M. Gorman and Leonard A. Rosenblum and Michael J. Owens and Charles B. Nemeroff},
  journal={Psychoneuroendocrinology},
  year={2011},
  volume={36 2},
  pages={289-93}
}
Recent studies have indicated a gene-by-environment interaction between serotonin transporter gene (5-HTTLPR) polymorphism and childhood abuse on depressive symptoms. In addition, persistent elevation of cerebrospinal fluid (CSF) corticotropin-releasing factor (CRF) concentrations following early-life adversity has been posited to underlie the subsequent development of major depression. This pilot study tested the hypothesis that elevations of juvenile CSF CRF concentrations are, in part… CONTINUE READING

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