Early-life stress, corpus callosum development, hippocampal volumetrics, and anxious behavior in male nonhuman primates.

@article{Jackowski2011EarlylifeSC,
  title={Early-life stress, corpus callosum development, hippocampal volumetrics, and anxious behavior in male nonhuman primates.},
  author={Andrea Parolin Jackowski and T. J. D. R. Perera and Chadi G. Abdallah and Griselda J. Garrido and Cheuk Y. Tang and Jos{\'e} M a. Serrano Mart{\'i}nez and Sanjay J. Mathew and J. M. Gorman and Leonard A. Rosenblum and Eric L. P. Smith and Andrew J. Dwork and Dikoma C. Shungu and Arie Kaffman and Joel Gelernter and Jeremy D. Coplan and J. G. Kaufman},
  journal={Psychiatry research},
  year={2011},
  volume={192 1},
  pages={37-44}
}
Male bonnet monkeys (Macaca radiata) were subjected to the variable foraging demand (VFD) early stress paradigm as infants, MRI scans were completed an average of 4 years later, and behavioral assessments of anxiety and ex-vivo corpus callosum (CC) measurements were made when animals were fully matured. VFD rearing was associated with smaller CC size, CC measurements were found to correlate with fearful behavior in adulthood, and ex-vivo CC assessments showed high consistency with earlier MRI… CONTINUE READING