Early-life sodium exposure unmasks susceptibility to stroke in hyperlipidemic, hypertensive heterozygous Tg25 rats transgenic for human cholesteryl ester transfer protein.

@article{Decano2009EarlylifeSE,
  title={Early-life sodium exposure unmasks susceptibility to stroke in hyperlipidemic, hypertensive heterozygous Tg25 rats transgenic for human cholesteryl ester transfer protein.},
  author={Julius L. Decano and Jason C Viereck and Ann C. McKee and James Peter Hamilton and Nelson Ruiz-Opazo and Victoria L. M. Herrera},
  journal={Circulation},
  year={2009},
  volume={119 11},
  pages={1501-9}
}
BACKGROUND Early-life risk factor exposure increases aortic atherosclerosis and blood pressure in humans and animal models; however, limited insight has been gained as to end-organ complications. METHODS AND RESULTS We investigated the effects of early-life Na exposure (0.23% versus 0.4% NaCl regular rat chow) on vascular disease outcomes using the inbred, transgenic [hCETP](25) Dahl salt-sensitive hypertensive rat model of male-predominant coronary atherosclerosis, Tg25. Rather than the… CONTINUE READING