Early-life seizures in rats increase susceptibility to seizure-induced brain injury in adulthood.

@article{Koh1999EarlylifeSI,
  title={Early-life seizures in rats increase susceptibility to seizure-induced brain injury in adulthood.},
  author={Sookyong Koh and Thomas W Storey and Tatiane Oliveira Santos and A. Mian and Andrew J. Cole},
  journal={Neurology},
  year={1999},
  volume={53 5},
  pages={915-21}
}
BACKGROUND Early childhood convulsions have been correlated with the finding of subsequent hippocampal neuronal loss and memory impairment in patients with intractable temporal lobe epilepsy. There is little direct evidence, however, that links early seizures with the later development of epilepsy and selective hippocampal neuronal loss. OBJECTIVE To study the long-term effect of early seizures on later seizure-induced neuronal damage and behavior. METHODS We used a "two hit" rat seizure… CONTINUE READING