Early life adversity, genomic plasticity, and psychopathology.

  title={Early life adversity, genomic plasticity, and psychopathology.},
  author={Gustavo Turecki and Vanessa Kiyomi Arashiro Ota and Sintia I Belangero and Andrea Parolin Jackowski and Joan Kaufman},
  journal={The lancet. Psychiatry},
  volume={1 6},
Child maltreatment is associated with an increased risk of psychiatric disorders, and a range of health problems later in life. Research suggests that adverse events early in life can lead to changes in gene expression through epigenetic mechanisms that alter stress reactivity, brain function, and behaviour. Although epigenetic changes are often long lasting, they can be reversed with pharmacological and environmental manipulations. The complexity of the epigenome is not fully understood. The… CONTINUE READING
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