Early kinetics of glucagon action in isolated hepatocytes at the mitochondrial level.

@article{Siess1980EarlyKO,
  title={Early kinetics of glucagon action in isolated hepatocytes at the mitochondrial level.},
  author={E. A. Siess and Otto H. Wieland},
  journal={European journal of biochemistry},
  year={1980},
  volume={110 1},
  pages={
          203-10
        }
}
  • E. A. Siess, Otto H. Wieland
  • Published 1980
  • Biology, Medicine
  • European journal of biochemistry
  • The temporal relationship between the effect of glucagon on respiratory functions and the changes in metabolites related to gluconeogenesis has been studied. Mitochondria prepared from hepatocytes after incubation with glucagon for 1 min already displayed a maximal stimulation of state-3 respiration. The increase in succinate dehydrogenase activity was almost fully expressed 3 min after glucagon. With respect to the utilization of pyruvate, 2-oxoglutarate and glutamate, glucagon produced a… CONTINUE READING