Early ketamine to treat refractory status epilepticus.

  title={Early ketamine to treat refractory status epilepticus.},
  author={Andreas H Kramer},
  journal={Neurocritical care},
  volume={16 2},
BACKGROUND Management of refractory status epilepticus (SE) involves administration of intravenous γ-aminobutyric acid (GABA(A)) receptor agonists, such as benzodiazepines, barbiturates, or propofol. Animal models suggest that reductions in synaptic GABA(A) receptors may cause these drugs to become less effective as the duration of SE increases. This may explain the large doses that are commonly required to control seizures, which in turn contributes to a high incidence of complications… CONTINUE READING