Early involvement of the phosphatidylinositol 3-kinase/Akt pathway in lung cancer progression.

  title={Early involvement of the phosphatidylinositol 3-kinase/Akt pathway in lung cancer progression.},
  author={Pierre P. Massion and Peter M Taflan and Yu Shyr and S. M. Jamshedur Rahman and Pinar {\"O} Yildiz and Bashar Shakthour and Mary E. Edgerton and Matthew Ninan and Jeremiah J Andersen and Adriana L. Gonzalez},
  journal={American journal of respiratory and critical care medicine},
  volume={170 10},
Signaling through the phosphatidylinositol 3-kinase (PI3-kinase) pathway has been associated with lung tumorigenesis. We examined the association between gene copy number of the PI3-kinase catalytic subunit alpha (PIK3CA) and phosphorylated Akt expression in invasive and preinvasive lung cancers. We sought to determine at what stage of tumor development gene copy number increase or phosphorylated Akt overexpression might affect tumor development. We assessed PIK3CA gene copy number by… CONTINUE READING
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Chromosome 3q amplification as a candidate biomarker for lung cancer progression

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  • Am J Respir Crit Care Med 167(7):A813
  • 2003
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