Early involvement of small inhibitory cortical interneurons in Alzheimer’s disease

  title={Early involvement of small inhibitory cortical interneurons in Alzheimer’s disease},
  author={Vassilis E. Koliatsos and Aleksandar Kecojevic and Juan C Troncoso and Myriam C. Gastard and David A. Bennett and Julie A Schneider},
  journal={Acta Neuropathologica},
Work on acute models of cortical injury has revealed a population of small GABAergic interneurons that are induced to increase their low constitutive expression of neuronal nitric oxide (NO) synthase (nNOS). In some cases, this activation may play a role in NO-mediated degeneration of pyramidal neurons. In this report, we explore the anatomy of various classes of cortical nNOS (+) (nitrergic) neurons, with emphasis on small interneurons, in the medial temporal lobe of subjects with Alzheimer’s… CONTINUE READING


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